2977: For many years a mighty battle has been raging across the galaxies as 500 billion humans, whose forebears were exiled from Earth, plan to return to what is still called home. Forced to flee a ravaged Earth, humans have now depleted the corners of the galaxy to which they fled. Earth has now become the most valued and precious resource of all, controlled by the corrupt Gaia Coalition which governs the human race across the different galaxies. Having been exiled and vilified during the battle of the Homecoming War, Captain Harlock and his trusted crew of the Arcadia battle cruiser are the only hope mankind has of discovering the secrets that the Gaia have kept hidden. The Coalition has demanded Harlock's death and the Gaia Fleet's new leader, Ezra, calls on his younger brother, Logan, to infiltrate the Arcadia and then assassinate Harlock, thus forever eradicating the one man standing between the Coalition and their complete control of the Universe. Logan must make a very personal...

Gibson Rickenbacker is a hired fighter living in a plague-ravaged apocalyptic America where a plague has infested most of the United States and the rest of the world. In New York City, Gibson encounters a woman named Pearl Prophet. Pearl reveals to Gibson that she is a cyborg who is carrying vital-information for a group of scientists in Atlanta who are working on a cure to the plague and Pearl hires Gibson to escort her back to Atlanta. But Pearl is kidnapped by "Pirates" a murderous gang led by Fender Tremolo, who wants the cure for themselves and they decide to take Pearl to Atlanta themselves. Gibson, joined by a young woman named Nady Simmons, goes in pursuit of Fender and his gang, as Gibson sets out to rescue Pearl, stop Fender and his gang from reaching Atlanta and defeat Fender who slaughtered Gibson's family.